Invention Grant
- Patent Title: Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
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Application No.: US13988158Application Date: 2011-11-17
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Publication No.: US09808461B2Publication Date: 2017-11-07
- Inventor: Derek P. DiRocco , Norman E. Sharpless , Jay C. Strum , John E. Bisi , Patrick J. Roberts , Benjamin D. Humphreys , Kwok-Kin Wong
- Applicant: Derek P. DiRocco , Norman E. Sharpless , Jay C. Strum , John E. Bisi , Patrick J. Roberts , Benjamin D. Humphreys , Kwok-Kin Wong
- Applicant Address: US NC Chapel Hill US NC Chapel Hill US MA Boston
- Assignee: The University of North Carolina at Chapel Hill,G1 Therapeutics,Brigham and Women's Hospital
- Current Assignee: The University of North Carolina at Chapel Hill,G1 Therapeutics,Brigham and Women's Hospital
- Current Assignee Address: US NC Chapel Hill US NC Chapel Hill US MA Boston
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- International Application: PCT/US2011/061202 WO 20111117
- International Announcement: WO2012/068381 WO 20120524
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/519 ; A61K31/192 ; A61K31/436 ; A61K31/616 ; A61K38/13 ; A61K31/505
Abstract:
The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.
Public/Granted literature
- US20130303543A1 PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 Public/Granted day:2013-11-14
Information query
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