Invention Grant
- Patent Title: Glycosidase inhibitors and uses thereof
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Application No.: US14424873Application Date: 2013-08-29
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Publication No.: US09809537B2Publication Date: 2017-11-07
- Inventor: Ernest J. McEachern , Jianyu Sun , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
- Applicant: Alectos Therapeutics Inc. , Merck Sharp & Dohme Corp.
- Applicant Address: CA Burnaby US NJ Rahway
- Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CA Burnaby US NJ Rahway
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2013/050672 WO 20130829
- International Announcement: WO2014/032188 WO 20140306
- Main IPC: C07D207/12
- IPC: C07D207/12 ; A61K31/40 ; A61K31/428 ; A61K31/4439 ; C07D401/06 ; C07D417/06 ; C12N9/99 ; C07D207/16
Abstract:
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20150274656A1 GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2015-10-01
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