Invention Grant
- Patent Title: Transforming growth factor beta receptor II fusion polypeptides
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Application No.: US15044883Application Date: 2016-02-16
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Publication No.: US09809637B2Publication Date: 2017-11-07
- Inventor: Ravindra Kumar , Asya Grinberg , Dianne S. Sako , Roselyne Castonguay , Rita Steeves
- Applicant: Acceleron Pharma Inc.
- Applicant Address: US MA Cambridge
- Assignee: ACCLERON PHARMA INC.
- Current Assignee: ACCLERON PHARMA INC.
- Current Assignee Address: US MA Cambridge
- Agency: White & Case LLP
- Main IPC: C07K14/71
- IPC: C07K14/71 ; C07K14/495 ; C07K16/22 ; A61K38/00
Abstract:
In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of TβRII polypeptide useful to selectively antagonize a TβRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFβ associated disorders.
Public/Granted literature
- US20160376341A1 TGF-BETA RECEPTOR TYPE II VARIANTS AND USES THEREOF Public/Granted day:2016-12-29
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