Invention Grant
- Patent Title: Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression
-
Application No.: US12677035Application Date: 2008-09-25
-
Publication No.: US09809797B2Publication Date: 2017-11-07
- Inventor: Cassian Yee , Yongqing Li
- Applicant: Cassian Yee , Yongqing Li
- Applicant Address: US DC Washington
- Assignee: NATIONAL INSTITUTES OF HEALTH (NIH) U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY
- Current Assignee: NATIONAL INSTITUTES OF HEALTH (NIH) U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY
- Current Assignee Address: US DC Washington
- Agency: McBee Moore Woodward & Vanik IP, LLC
- Agent Susan McBee
- International Application: PCT/US2008/011088 WO 20080925
- International Announcement: WO2009/045308 WO 20090409
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K31/41 ; A61K39/00 ; A61K35/17 ; A61K35/12

Abstract:
A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.
Public/Granted literature
- US20100330056A1 ENHANCED GENERATION OF CYTOTOXIC T-LYMPHOCYTES BY IL-21 MEDIATED FOXP3 SUPPRESSION Public/Granted day:2010-12-30
Information query