An image sensing device may include one or more compression modules that compress digitized pixel reset values obtained from light sensing elements. The device may perform a CDS operation in which the compressed reset values are stored, decompressed, and then subtracted from light dependent values obtained from the light sensing elements. The compressed reset values may also be output from the device without CDS subtraction having been performed. The light dependent values may also be compressed. CDS corrected output pixel values may also be compressed.