A hands-free audio device has a receive path and a transmit path, which may operate at different audio sampling rates. The transmit path has an interference suppressor that receives a reference signal from the receive path and that suppresses interference in microphone signals received from a microphone array. The interference suppressor is followed in the transmit path by a multi-channel adaptive beamformer that produce a plurality of directional audio signals. A beam selector is configured to select one of the directional audio signals based on voice activity, echo detection, and signal energy.