Invention Grant
- Patent Title: Lyophilized formulation comprising GM-CSF neutralizing compound
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Application No.: US14428489Application Date: 2013-10-31
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Publication No.: US09833410B2Publication Date: 2017-12-05
- Inventor: Markus Rast , Wolfram Steinhilber , Christian de Muynck , Gerhard Becker , Pernille Dybendal Pedersen , Thomas Urbig , Thomas Boehm
- Applicant: Amgen Research (Munich) GmbH , Takeda GmbH
- Applicant Address: DE Constance DE Munich
- Assignee: Takeda GmbH,Amgen Research (Munich) GmbH
- Current Assignee: Takeda GmbH,Amgen Research (Munich) GmbH
- Current Assignee Address: DE Constance DE Munich
- Agency: DLA Piper LLP (US)
- Priority: EP12199199 20121221
- International Application: PCT/EP2013/072766 WO 20131031
- International Announcement: WO2014/068029 WO 20140508
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; A61K9/19 ; A61K47/22 ; A61K47/18 ; A61K47/26 ; C07K16/24

Abstract:
The present invention relates to aqueous formulations comprising at least 20 mg/ml of a compound neutralizing GM-CSF, a lyoprotectant and an amino acid and/or a buffer. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of lyophilization, storage and reconstruction. In a preferred aspect, the formulation, e.g. after reconstruction, is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.
Public/Granted literature
- US20150342888A1 LYOPHILIZED FORMULATION COMPRISING GM-CSF NEUTRALIZING COMPOUND Public/Granted day:2015-12-03
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