Invention Grant
- Patent Title: NKP30 receptor targeted therapeutics
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Application No.: US14342060Application Date: 2012-08-31
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Publication No.: US09833476B2Publication Date: 2017-12-05
- Inventor: Tong Zhang , Charles L. Sentman
- Applicant: Tong Zhang , Charles L. Sentman
- Applicant Address: US NH Hanover
- Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee Address: US NH Hanover
- Agency: LeClairRyan, A Professional Corporation
- Agent Robin L. Teskin
- International Application: PCT/US2012/053511 WO 20120831
- International Announcement: WO2013/033626 WO 20130307
- Main IPC: C07K14/70
- IPC: C07K14/70 ; A61K35/17 ; C07K14/705 ; C12N5/0783 ; A61K38/00

Abstract:
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.
Public/Granted literature
- US20150110760A1 NKP30 RECEPTOR TARGETED THERAPEUTICS Public/Granted day:2015-04-23
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