Invention Grant
- Patent Title: Combinations of a caspase inhibitor and an antiviral agent
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Application No.: US14713477Application Date: 2015-05-15
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Publication No.: US09833492B2Publication Date: 2017-12-05
- Inventor: Jerome Estaquier , Mireille Laforge , Anna Senik
- Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , UNIVERSITÉ PARIS-SUD
- Applicant Address: FR Paris FR Paris FR Pari FR Orsay
- Assignee: Institut Pasteur,Institut National de la Santé et de la Recherche Médicale,Centre National de la Recherche Scientifique,Universite Paris—Sud
- Current Assignee: Institut Pasteur,Institut National de la Santé et de la Recherche Médicale,Centre National de la Recherche Scientifique,Universite Paris—Sud
- Current Assignee Address: FR Paris FR Paris FR Pari FR Orsay
- Agency: Arrigo, Lee & Guttman LLP
- Priority: FR0707722 20071102
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K38/05 ; A61K45/06 ; A61K31/404 ; A61K31/4525 ; A61K31/496 ; A61K31/7072 ; A61K38/00 ; C07K5/062
Abstract:
A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxyl)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.
Public/Granted literature
- US20150246091A1 COMPOUNDS AND METHODS FOR PREVENTING OR TREATING A VIRAL INFECTION Public/Granted day:2015-09-03
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