A medical injector is provided herein which includes first and second body portions each having a longitudinal axis and configured to couple at a coupling. The medical injector also includes an axially-displaceable plunger; biasing element for advancing the plunger a predetermined distance; and, a releasable retainer for releasably retaining the plunger in a first state against the force of the biasing element. In an initial state, the axes of the first and second body portions are not aligned and the plunger is in the first state. In a coupled state, the axes of the first and second body portions are axially aligned, and the releasable retainer releases the plunger, thereby allowing the biasing element to advance the plunger the predetermined distance. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon assembly of the pen injector, thereby minimizing premature or failed activations.