Disclosed are electro-hydraulic brake system and control method. The system may include a braking input unit to provide a braking input according to an operation of a driver, a control unit to control generation of braking oil pressure according to the braking input of the braking input unit, a pressure generating unit to generate the braking oil pressure, wheel clamping units to generate braking forces to corresponding wheels, and oil supply lines to transfer the braking oil pressure to corresponding wheel clamping units. Each oil supply line is fluidly connected to the pressure generating unit. For each oil supply line, a split valve is installed in a connection portion of the pressure generating unit and the oil supply line. When the split valve is closed, the split valve blocks the braking oil pressure supplied from the pressure generating unit to the oil supply line.