Invention Grant
- Patent Title: Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and their use as pharmaceuticals
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Application No.: US14895695Application Date: 2014-06-05
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Publication No.: US09834527B2Publication Date: 2017-12-05
- Inventor: Andreas Evers , Christopher Kallus , Michael Wagner , Hermut Wehlan
- Applicant: SANOFI
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: EP13305779 20130610
- International Application: PCT/EP2014/061669 WO 20140605
- International Announcement: WO2014/198620 WO 20141218
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D273/01 ; A61K31/395 ; A61K31/4427 ; A61P7/02 ; A61K45/06 ; C07D213/75
Abstract:
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.
Public/Granted literature
- US20160137618A1 Macrocyclic Urea Derivatives as Inhibitors of TAFIa, Their Preparation and Their Use as Pharmaceuticals Public/Granted day:2016-05-19
Information query
