Invention Grant
- Patent Title: Antibodies to human programmed death receptor PD-1
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Application No.: US14576448Application Date: 2014-12-19
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Publication No.: US09834605B2Publication Date: 2017-12-05
- Inventor: Gregory John Carven , Hans Van Eenenneem , Gradus Johannes Dulos
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: NL Haarlem
- Assignee: Merck Sharpe & Dohme B.V.
- Current Assignee: Merck Sharpe & Dohme B.V.
- Current Assignee Address: NL Haarlem
- Agent Alysia A. Finnegan; Gloria M. Fuentes
- Main IPC: C07K16/28
- IPC: C07K16/28 ; G01N33/574 ; G01N33/68

Abstract:
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.
Public/Granted literature
- US20160304606A9 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 Public/Granted day:2016-10-20
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