Invention Grant
- Patent Title: Fusion proteins for modulating regulatory and effector T cells
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Application No.: US14764024Application Date: 2014-01-31
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Publication No.: US09834610B2Publication Date: 2017-12-05
- Inventor: Mark L. Tykocinski
- Applicant: Thomas Jefferson University , The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia US PA Philadelphia
- Assignee: Thomas Jefferson University,The Trustees of the University of Pennsylvania
- Current Assignee: Thomas Jefferson University,The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- International Application: PCT/US2014/014197 WO 20140131
- International Announcement: WO2015/116178 WO 20150806
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/28 ; C07K14/705 ; C07K14/525 ; A61K39/395 ; A61K38/19 ; C07K14/52
Abstract:
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention are useful in modulating both regulatory T (Treg) cells and effector T (Teff) cells.
Public/Granted literature
- US20160347846A1 FUSION PROTEINS FOR MODULATING REGULATORY AND EFFECTOR T CELLS Public/Granted day:2016-12-01
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