Invention Grant
- Patent Title: Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them
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Application No.: US15025406Application Date: 2014-09-26
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Publication No.: US09834775B2Publication Date: 2017-12-05
- Inventor: George M. Church , Daniel J. Mandell , Marc J. Lajoie
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2014/057573 WO 20140926
- International Announcement: WO2015/048364 WO 20150402
- Main IPC: C12N15/52
- IPC: C12N15/52 ; C12N1/36 ; C12N15/65
Abstract:
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
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