Invention Grant
- Patent Title: Nuclease-mediated targeting with large targeting vectors
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Application No.: US13870280Application Date: 2013-04-25
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Publication No.: US09834786B2Publication Date: 2017-12-05
- Inventor: David Frendewey , Wojtek Auerbach , David M. Valenzuela , George D. Yancopoulos , Ka-Man Venus Lai
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Alston & Bird LLP
- Agent Yongjin Choi
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C07K14/715 ; C12N15/90
Abstract:
Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double-strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target genomic locus in prokaryotic or eukaryotic cells using engineered nucleases are also provided.
Public/Granted literature
- US20130309670A1 Nuclease-Mediated Targeting With Large Targeting Vectors Public/Granted day:2013-11-21
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