Invention Grant
- Patent Title: Production of high levels of DHA-containing biomass in microalgae using modified amounts of chloride and potassium
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Application No.: US14975670Application Date: 2015-12-18
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Publication No.: US09834799B2Publication Date: 2017-12-05
- Inventor: Paul W Behrens , John M Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
- Applicant: DSM IP Assets B.V.
- Applicant Address: NL TE Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL TE Heerlen
- Agent Shannon McGarrah; Xi Chen
- Main IPC: C12P7/64
- IPC: C12P7/64 ; A61K36/02 ; C11B1/10
Abstract:
Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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