A door opening and closing apparatus includes a rail module including: a rail member extending along a front-and-rear direction; a drive device mounted on the rail member; and a supporting member coupled to one end portion of a closing cable the other end portion of which is connected to the drive device and one end portion of an opening cable the other end portion of which is connected to the drive device. The rail module is provided with the drive device fastened to an outside of a vehicle body such that a part of the drive device goes inside the vehicle body through an opening provided on the vehicle body. At least the opening inversion member is provided at an upper portion of the other end portion of the rail member.