Invention Grant
- Patent Title: Isolation of pulmonary arterial endothelial cells from patients with pulmonary vascular disease and uses thereof
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Application No.: US14426488Application Date: 2013-09-10
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Publication No.: US09835617B2Publication Date: 2017-12-05
- Inventor: Michael J. Passineau , Srinivas Murali , Raymond L. Benza , Jonathan B. Pollett
- Applicant: Allegheny-Singer Research Institute
- Applicant Address: US PA Pittsburgh
- Assignee: Allegheny-Singer Research Institute
- Current Assignee: Allegheny-Singer Research Institute
- Current Assignee Address: US PA Pittsburgh
- Agency: Fox Rothschild LLP
- International Application: PCT/US2013/058897 WO 20130910
- International Announcement: WO2014/040020 WO 20140313
- Main IPC: C12N5/00
- IPC: C12N5/00 ; G01N33/50 ; C12N5/071 ; A61B10/02 ; A61M25/10
Abstract:
The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient, subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.
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