Example systems and methods of Interaction with a native user interface via a web-based user interface are presented. In one example, a web-based transaction identifying a function to be executed in a processing system is launched in a web-based user interface session. A web application is invoked in the web-based transaction. A native user interface session is initiated from the web application. A native adapter transaction based on the web-based transaction is launched in the native user interface session. Execution of the function in the processing system is initiated in the native adapter transaction.