An automated medication adherence system. The automated medication adherence system may comprise: a housing, an electronic interface, a plurality of reservoirs, one or more sensors, and at least one pill delivery and lock-out module. The electronic interface is programmable to accept data relating to a medication, including at least one of a pill identify, a user identity, a dosage schedule, and a side effect. The electronic interface actuates rotation of a reservoir, which is configured to receive, store, and dispense pills, tablets, and capsules of various sizes accurately and precisely. The sensors monitor medication input and output, and alerts a user when medication has been dispensed and needs to be taken.