Systems and methods for selective authorization of code modules are provided. According to one embodiment, a kernel mode driver monitors events occurring within a file system or an operating system. Responsive to observation of a trigger event performed by or initiated by an active process, in which the active process corresponds to a first code module within the file system and the event relates to a second code module within the file system, performing or bypassing a real-time authentication process on the second code module with reference to a multi-level whitelist database architecture. The active process is allowed to load the second code module into memory when the real-time authentication process is bypassed or when it is performed and results in an affirmative determination.