A frame utilized in a fingerprint recognition plate, a manufacturing method thereof, and a light guide mechanism with the frame including the frame with a hollow portion, light emitting diodes, and a light guide plate. The manufacturing method includes: forming a frame containing mixed materials having plastic materials and metallic materials in a manner of injection molding, forming patterns on the frame in a manner of laser engraving, and forming electric conductive portions in the patterns of the frame in a manner of electroplating or electroless plating. The frame is formed with electric conductive circuit. The light emitting diodes are mounted on the electric conductive portions of the frame by surface mount technology (SMT) process. Light rays emitted by the light emitting diodes can be transmitted in the light guide plate. When the frame is formed via the laser engraving process combining with electroplating process, the frame can be minimized.