Invention Grant
- Patent Title: Inhibitors of NEDD8-activating enzyme
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Application No.: US14326051Application Date: 2014-07-08
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Publication No.: US09850214B2Publication Date: 2017-12-26
- Inventor: Ashley Sue McCarron , Todd B. Sells , Matthew Stirling , Stephen G. Stroud
- Applicant: Millennium Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: MILLENNIUM PHARMACEUTICALS, INC.
- Current Assignee: MILLENNIUM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Sterne, Kessler, Goldstein and Fox P.L.L.C.
- Main IPC: A61K31/505
- IPC: A61K31/505 ; C07D239/02 ; C07D239/47 ; C07D239/46 ; C07D473/02

Abstract:
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
Public/Granted literature
- US20150011572A1 INHIBITORS OF NEDD8-ACTIVATING ENZYME Public/Granted day:2015-01-08
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