Invention Grant
- Patent Title: Neutralization of CD95 activity blocks invasion of glioblastoma cells in vivo
-
Application No.: US14700521Application Date: 2015-04-30
-
Publication No.: US09850308B2Publication Date: 2017-12-26
- Inventor: Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
- Applicant: Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts , Universitaetsklinikum Heidelberg
- Applicant Address: DE Heidelberg DE Heidelberg
- Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS,UNIVERSITAETSKLINIKUM HEIDELBERG
- Current Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS,UNIVERSITAETSKLINIKUM HEIDELBERG
- Current Assignee Address: DE Heidelberg DE Heidelberg
- Agency: Perkins Coie LLP
- Agent Viola T. Kung
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K14/705 ; G01N33/566 ; G01N33/574 ; A61K38/00 ; G01N33/68 ; A61K39/00
Abstract:
The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
Public/Granted literature
- US20160115236A1 NEUTRALIZATION OF CD95 ACTIVITY BLOCKS INVASION OF GLIOBLASTOMA CELLS IN VIVO Public/Granted day:2016-04-28
Information query
