Invention Grant
- Patent Title: Biomarkers associated with BRM inhibition
-
Application No.: US14777211Application Date: 2014-03-12
-
Publication No.: US09850543B2Publication Date: 2017-12-26
- Inventor: Zainab Jagani , Gregory Hoffman , Frank Peter Stegmeier , Craig Stephen Mickanin
- Applicant: Zainab Jagani , Gregory Hoffman , Frank Peter Stegmeier , Craig Stephen Mickanin
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Hong-Van M. Le
- International Application: PCT/US2014/024128 WO 20140312
- International Announcement: WO2014/150751 WO 20140925
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12Q1/68 ; C12N15/113 ; G01N33/574 ; C12N5/00
Abstract:
The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.
Public/Granted literature
- US20160032402A1 BIOMARKERS ASSOCIATED WITH BRM INHIBITION Public/Granted day:2016-02-04
Information query
