An article of footwear is disclosed below as having an upper and a sole structure secured to the upper. The sole structure includes a perimeter chamber, a central chamber, and an outsole. The perimeter chamber extends adjacent to at least a portion of a lateral sidewall and a medial sidewall of the sole structure. The central chamber is positioned within a central area of the sole structure, the central area being located between the lateral sidewall and the medial sidewall. The outsole defines at least a portion of a lower surface of the sole structure, and has a perimeter section secured below the perimeter chamber and a central section secured below the central chamber. Various features may be incorporated into the sole structure. For example, the perimeter chamber may be spaced from the central chamber and the perimeter section may be spaced from the central section to define a gap extending upward and into the sole structure from the lower surface.