A method and system is provided for noise cleaning of photoplethysmogram signals. The method and system is disclosed for noise cleaning of photoplethysmogram signals for estimating blood pressure of a user; wherein photoplethysmogram signals are extracting from the user; the extracted photoplethysmogram signals are up sampled; the up sampled photoplethysmogram signals are filtered; uneven baseline drift of each cycle is removed from the up sampled and filtered photoplethysmogram signals; outlier cycles of the photoplethysmogram signals are removed and remaining cycles of the photoplethysmogram signals are modeled; and time domain features are extracted from originally extracted and modeled photoplethysmogram signals for estimating blood pressure of the user.