Intravascular devices, systems, and methods are provided. In one embodiment, an intravascular system includes an intravascular device and a computing device in communication with the intravascular device, the computing device operable to: present a set of mode options to a user at a user display device; receive a mode selection from the presented set of mode options; determine a set of operating parameters based on the mode selection; receive a first set of medical sensing data; and process the first set of medical sensing data according to the operating parameters, wherein the computing device is further operable to determine the set of operating parameters based on at least one of a previous mode selection, a user preference, an operative course of a medical procedure, patient information, the first set of medical sensing data, a second set of medical sensing data, a status indicator, or a sensing device identifier.