Invention Grant
- Patent Title: Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
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Application No.: US14802046Application Date: 2015-07-17
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Publication No.: US09855232B2Publication Date: 2018-01-02
- Inventor: Ke Wu , Shaoxin Feng , Thomas K. Karami , Scott W. Smith
- Applicant: Allergan, Inc.
- Applicant Address: US CA Irvine
- Assignee: ALLERGAN, INC.
- Current Assignee: ALLERGAN, INC.
- Current Assignee Address: US CA Irvine
- Agent Jonathan Bass
- Main IPC: A61K31/192
- IPC: A61K31/192 ; C07C59/54 ; A61K9/00
Abstract:
The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
Public/Granted literature
- US20160175269A1 CRYSTALLINE FORMS OF BIMATOPROST ACID, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF Public/Granted day:2016-06-23
Information query
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