Invention Grant
- Patent Title: Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG
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Application No.: US14536299Application Date: 2014-11-07
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Publication No.: US09855233B2Publication Date: 2018-01-02
- Inventor: Samuel Rahbar , Timothy W. Synold , John Termini
- Applicant: CITY OF HOPE , Mahin Rahbar
- Applicant Address: US CA Duarte
- Assignee: CITY OF HOPE
- Current Assignee: CITY OF HOPE
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Agent Lara J. Dueppen; Courtney Prochnow
- Main IPC: G01N30/72
- IPC: G01N30/72 ; A61K31/195 ; G01N30/04 ; G01N30/88 ; A61K45/06 ; A61N5/10
Abstract:
Methods of quantifying a N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.
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