Invention Grant
- Patent Title: Pharmaceutical composition comprising CCN5 for reducing cardiac fibrosis in a subject in need thereof
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Application No.: US13636500Application Date: 2011-03-10
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Publication No.: US09855315B2Publication Date: 2018-01-02
- Inventor: Woo Jin Park , Pyoung Oh Yoon , Dong Kwon Yang
- Applicant: Woo Jin Park , Pyoung Oh Yoon , Dong Kwon Yang
- Applicant Address: KR Buk-Gu, Gwangju
- Assignee: BETHPHAGEN INC.
- Current Assignee: BETHPHAGEN INC.
- Current Assignee Address: KR Buk-Gu, Gwangju
- Agency: Harness, Dickey & Pierce, P.L.C.
- Priority: KR10-2010-0025109 20100322
- International Application: PCT/KR2011/001685 WO 20110310
- International Announcement: WO2011/118928 WO 20110929
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K38/18 ; C07K14/475 ; G01N33/68 ; A61K31/7088 ; A61K38/17 ; A01K67/027
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating a heart failure and a method for screening a therapeutic agent for preventing or treating a heart failure. The pharmaceutical composition of the present disclosure comprises the CCN5 or CCN2ΔCT protein, or a genetic carrier comprising a nucleotide sequence encoding the CCN5 or the CCN2ΔCT protein, exhibiting dramatic prevention or treatment efficacies on a heart failure even without surgical treatments accompanied with transplanting a donor heart.
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