Invention Grant
- Patent Title: Pharmaceutical preparation of camptothecin-containing polymer derivative
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Application No.: US15515295Application Date: 2015-10-16
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Publication No.: US09855339B2Publication Date: 2018-01-02
- Inventor: Shinya Fujita , Shin Aoki
- Applicant: Nippon Kayaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nields, Lemack & Frame, LLC
- Priority: JP2014-263848 20141226
- International Application: PCT/JP2015/079314 WO 20151016
- International Announcement: WO2016/103867 WO 20160630
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07D491/00 ; A61K31/44 ; A61K38/00 ; A61K47/48 ; A61K9/08 ; A61K9/19 ; A61K31/4745 ; C08G81/00

Abstract:
Provided is a pharmaceutical preparation composition comprising a polymerized camptothecin derivative which is obtained by bonding a camptothecin derivative to a polymer carrier, and has nanoparticle-forming properties of associating in an aqueous solution, the pharmaceutical preparation composition having enhanced preparation stability. Particularly, a pharmaceutical preparation maintaining nanoparticle-forming properties, which are an important factor, and having an excellent storage stability is provided.Disclosed is a pharmaceutical preparation comprising a block copolymer in which a polyethylene glycol segment is linked to a polyglutamic acid segment containing a glutamic acid unit having a camptothecin derivative bonded thereto, the pharmaceutical preparation capable of forming associates in an aqueous solution. When the pharmaceutical preparation is made into an aqueous solution containing the camptothecin derivative at a concentration of 1 mg/mL, the pH of the aqueous solution is 2.4 to 7.0, and the change ratio of the associate-forming ability of the pharmaceutical preparation after storage at 40° C. for one week under light-blocked conditions is 50% or less.
Public/Granted literature
- US20170298190A1 Pharmaceutical Preparation Of Camptothecin-Containing Polymer Derivative Public/Granted day:2017-10-19
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