Invention Grant
- Patent Title: Energy-providing bone-repair degradable porous scaffold, preparation method thereof, and application thereof
-
Application No.: US15130361Application Date: 2016-04-15
-
Publication No.: US09855366B2Publication Date: 2018-01-02
- Inventor: Shengmin Zhang , Mingle Cai , Haoming Liu
- Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
- Applicant Address: CN Wuhan
- Assignee: Huazhong University of Science and Technology
- Current Assignee: Huazhong University of Science and Technology
- Current Assignee Address: CN Wuhan
- Agency: Kolisch Hartwell, P.C.
- Priority: CN201610108128 20160226
- Main IPC: A61L27/18
- IPC: A61L27/18 ; A61L27/22 ; A61L27/54 ; A61L27/58 ; A61L27/56

Abstract:
The invention discloses an energy-providing bone-repair degradable porous scaffold, a preparation method thereof, and an application thereof. The invention obtains an energy-based biomaterial solution by compositing gelatin, a polyatomic acid and derivatives thereof, a dibasic alcohol and derivatives thereof, and a tribasic alcohol and derivatives thereof in a chemical cross-linking manner by using diisocyanate, and further obtains a porous scaffold through a drying method. The porous scaffold can avoid the problem of an acidic microenvironment caused by in vivo implantation of the existing biomaterial and keep the activity of an osteoblast cell, thereby improving the rate of repairing the damaged bone tissue with the energy-based biomaterial. The porous scaffold of the invention can be used as a filling material for bone repair in a surgical operation.
Public/Granted literature
Information query