Casting methods and articles are disclosed wherein a molten first material is introduced into a mold which distributes the first material to form a first region of the article where it is subjected to a first condition suitable for growing a first grain structure, forming the first region of the article. A molten second material, compositionally distinct from the first material, is introduced into the mold to form a second region of the article. A hybridized material is formed by intermixing a first portion of the second material with the second portion of the first material. A second portion of the second material is subjected to a second condition suitable for growing a second grain structure distinct from the first grain structure, forming the second region of the article. The first region and the second region are integrally formed as a single, continuous article with a hybridized region formed between.