The present invention relates to a method for controlling the operation of a printing press and a flexographic printing press for implementing said method, wherein the method comprises performing the following steps: a) capturing information from at least one image printed by said printing press; and b) comparing said information captured from said printed image with at least some digital-format information predetermined in prepress, or digital prepress information, including at least one part of the image to be printed. The method comprises adjusting the pressure and/or register setting of one or more printing units of the printing press, using at least the result of the comparison in said step b). The press is designed in order to implement the method.