The present invention provides an integrated control device of hydraulic brake for a handlebar of bicycle. The integrated control device includes a brake actuator of hydraulic type mounted on a housing body. The housing body comprises a handgrip portion and an attachment portion to the bicycle handlebar. The brake actuator includes a brake lever hinged on the housing body through a pin. A hydraulic cylinder is provided wherein a slidable piston is slidable that is kinematically connected to the brake lever through kinematic connection elements. A tank for hydraulic fluid is in fluid communication with the hydraulic cylinder. The control device includes an autonomous cartridge that comprises the hydraulic cylinder and the tank, and is removably inserted into a corresponding seat of the housing body. The seat is formed in a head portion of the housing body that is substantially opposite the attachment portion.