A method and device for controlling at least one actuator control system of an aircraft, an associated computer program product and aircraft are disclosed. In one aspect, the method includes determining a variation in thrust of the aircraft for controlling a variable relating to the aircraft relative to a set point, calculating a first control command signal to be sent to an engine control system in order to obtain the variation in thrust, and transmitting the first control command signal to the engine control system. The controlled variable can be an acceleration along a direction taken by a speed vector among the air speed vector and the ground speed vector and the set point can be an acceleration set point along the direction.