Invention Grant
- Patent Title: Methods to treat lymphoplasmacytic lymphoma
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Application No.: US15104132Application Date: 2014-12-12
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Publication No.: US09856223B2Publication Date: 2018-01-02
- Inventor: Steven P. Treon , Sara Jean Buhrlage , Nathanael S. Gray , Li Tan , Guang Yang
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2014/070162 WO 20141212
- International Announcement: WO2015/089479 WO 20150618
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D239/02 ; C07D239/47 ; A61K31/506 ; A61K45/06 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/04 ; C07D487/04

Abstract:
The present invention provides compounds of any one of Formulae (A), (I-11), (II), and (V) (e.g., compounds of Formula (A-1)-(A-18)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplasm in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase.
Public/Granted literature
- US20160318878A1 METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA Public/Granted day:2016-11-03
Information query
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