Invention Grant
- Patent Title: Therapeutics targeting truncated adenomatous polyposis coli (APC) proteins
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Application No.: US14482659Application Date: 2014-09-10
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Publication No.: US09856233B2Publication Date: 2018-01-02
- Inventor: Jef De Brabander , Jerry W. Shay , Wentian Wang
- Applicant: Jef De Brabander , Jerry W. Shay , Wentian Wang
- Applicant Address: US TX Austin
- Assignee: Board of Regents of the University of Texas System
- Current Assignee: Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: McCarter & English LLP
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D405/14 ; C07D471/08 ; C07D401/14 ; C07D413/14 ; C07D417/14 ; C07D211/96 ; C12N5/071
Abstract:
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic Epithelial Cell (HCEC) model, and pharmaceutical compositions comprising at least one of the small molecule anti-cancer compounds and a pharmaceutically acceptable carrier.
Public/Granted literature
- US20150232444A1 THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS Public/Granted day:2015-08-20
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