Invention Grant
- Patent Title: Substituted tropane derivatives
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Application No.: US15314020Application Date: 2015-05-28
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Publication No.: US09856250B2Publication Date: 2018-01-02
- Inventor: Hidekazu Masaki , Yoichi Iwasaki , Masayuki Kageyama , Yujiro Uchino
- Applicant: TOA EIYO LTD.
- Applicant Address: JP Chuo-ku
- Assignee: TOA EIYO LTD.
- Current Assignee: TOA EIYO LTD.
- Current Assignee Address: JP Chuo-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2014-109847 20140528
- International Application: PCT/JP2015/065471 WO 20150528
- International Announcement: WO2015/182724 WO 20151203
- Main IPC: C07D451/02
- IPC: C07D451/02 ; C07D519/00 ; A61K31/439

Abstract:
Provided is a compound which is useful as a prophylactic or therapeutic agent for various diseases in which T-type calcium channels are involved, such as hypertension, arrhythmia, pain and cancers, the compound having antagonistic activity against T-type calcium channels, being highly stable in the body and having low risk of, for example, genotoxicity. Disclosed is a compound represented by the following general formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein R1 represents —NH(C═O)—V—R3 or —(C═O)NH—V—R3; V represents a single bond, methylene, or —C(CH3)2O—; R2 represents a optionally substituted C1-6 alkyl group; X represents a hydrogen atom, an oxygen atom, a hydroxyl group, a methyl group, or a methylene group; A represents —NR6—, —O—CH2—, or —S—CH2—; n represents the number of methylene chains and represents an integer of 0, 1 or 2; and a doublet containing a dotted line represents a single bond or a double bond.
Public/Granted literature
- US20170190699A1 SUBSTITUTED TROPANE DERIVATIVES Public/Granted day:2017-07-06
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