Invention Grant
- Patent Title: Compositions and methods for modulation of LMNA expression
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Application No.: US14315186Application Date: 2014-06-25
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Publication No.: US09856473B2Publication Date: 2018-01-02
- Inventor: C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke , Timothy Vickers
- Applicant: Ionis Pharmaceuticls, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113
Abstract:
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
Public/Granted literature
- US20140309282A1 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION Public/Granted day:2014-10-16
Information query
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