Invention Grant
- Patent Title: Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis
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Application No.: US15035780Application Date: 2014-09-10
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Publication No.: US09856478B2Publication Date: 2018-01-02
- Inventor: Ta-Yuan Chang , Catherine C. Y. Chang , Li-Hao Huang , Elaina Melton , Paul Sohn
- Applicant: Trustees of Dartmouth College
- Applicant Address: US NH Hanover
- Assignee: TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee: TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2014/054917 WO 20140910
- International Announcement: WO2015/065595 WO 20150507
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/7105 ; A61K31/713 ; A61K9/127 ; A01K67/027
Abstract:
The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting Acyl-CoA:Cholesterol Acyltransferase 1 (ACATI) activity or expression in myeloid cells.
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