Invention Grant
- Patent Title: Chimeric proteins and methods of regulating gene expression
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Application No.: US15403058Application Date: 2017-01-10
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Publication No.: US09856497B2Publication Date: 2018-01-02
- Inventor: Lei S. Qi , P. C. Dave P. Dingal
- Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustee of the Leland Stanford Junior University
- Current Assignee: The Board of Trustee of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/90 ; C12N9/22
Abstract:
The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
Public/Granted literature
- US20170198308A1 Chimeric Proteins and Methods of Regulating Gene Expression Public/Granted day:2017-07-13
Information query
