Invention Grant
- Patent Title: Protease deubiquitinating inhibitor screening
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Application No.: US14344968Application Date: 2012-09-06
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Publication No.: US09856511B2Publication Date: 2018-01-02
- Inventor: Slavica Brnjic , Padraig D'Arcy , Rolf Larsson , Stig Linder
- Applicant: Slavica Brnjic , Padraig D'Arcy , Rolf Larsson , Stig Linder
- Applicant Address: SE Uppsala
- Assignee: VIVOLUX AB
- Current Assignee: VIVOLUX AB
- Current Assignee Address: SE Uppsala
- Agency: Porter Wright Morris & Arthur LLP
- Priority: SE1100678 20110916
- International Application: PCT/SE2012/000129 WO 20120906
- International Announcement: WO2013/039438 WO 20130321
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; C12Q1/34 ; G01N33/50 ; G01N33/573
Abstract:
A method for screening a compound to determine whether the compound is a proteasome deubiquitinating inhibitor of high specificity comprises contacting the compound with human 19S regulatory particles (19S RP) of 26S proteasome and determining whether the compound inhibits activity of deubiquitinating (DUB) enzymes UCHL5 and USP14; inhibition of UCHL5 and USCP14 activities indicates that the compound is a proteasome deubiquitinating inhibitor of high specificity.
Public/Granted literature
- US20140370528A1 Proteasome Deubiquinating Inhibitor Screening Public/Granted day:2014-12-18
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