Invention Grant
- Patent Title: Adeno-associated virus virions with variant capsid and methods of use thereof
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Application No.: US14606543Application Date: 2015-01-27
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Publication No.: US09856539B2Publication Date: 2018-01-02
- Inventor: David V. Schaffer , Ryan R. Klimczak , James T. Koerber , John G. Flannery , Deniz Dalkara Mourot , Meike Visel , Leah C. T. Byrne
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Paula A. Borden
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12Q1/70 ; A61K48/00 ; C07K14/005 ; C12N15/86 ; C12N7/00 ; G01N33/50 ; A61K9/00 ; A61K38/17 ; C12N15/113 ; C12N15/115
Abstract:
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
Public/Granted literature
- US20150225702A1 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF Public/Granted day:2015-08-13
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