A center supporting device for a propeller shaft of a vehicle may include an inner bearing device configured to axially movably support a stub shaft, the stub shaft being connected between a front shaft and a rear shaft of the propeller shaft, an outer bearing device mounted outside the inner bearing device to axially rotatably support the stub shaft, and an insulator mounted in an elastically deformable manner between the outside of the outer bearing device and a bracket fixed to a vehicle body.