Invention Grant
- Patent Title: Profiling fragments of elastic fibers and microfibrils as biomarkers for disease
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Application No.: US13280644Application Date: 2011-10-25
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Publication No.: US09857380B2Publication Date: 2018-01-02
- Inventor: Lynn Y. Sakai , Lynn M. Marshall , Eric J. Carlson , Noe L. Charbonneau , Susan J. Hayflick
- Applicant: Lynn Y. Sakai , Lynn M. Marshall , Eric J. Carlson , Noe L. Charbonneau , Susan J. Hayflick
- Applicant Address: US FL Tampa
- Assignee: SHRINERS HOSPITAL FOR CHILDREN
- Current Assignee: SHRINERS HOSPITAL FOR CHILDREN
- Current Assignee Address: US FL Tampa
- Agency: Baker Botts L.L.P.
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/68 ; A01K67/027 ; C07K14/78 ; C12N15/85
Abstract:
The present invention makes use of immunoassays, such as sandwich ELISAs, to profile the circulating concentration of elastic fiber and microfibril fragments in samples from individuals with diseases associated with elastic fiber and/or microfibril degradation. Examples of such diseases include, Marfan's syndrome, aortic aneurysm, and scleroderma. Profiling the concentration of such fragments can be used to diagnose disease and monitor disease progression.
Public/Granted literature
- US20120174244A1 PROFILING FRAGMENTS OF ELASTIC FIBERS AND MICROFIBRILS AS BIOMARKERS FOR DISEASE Public/Granted day:2012-07-05
Information query
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