A system and method for system table modification in a virtualized computer system are disclosed. In accordance with one embodiment, a hypervisor that is executed by a computer system detects a hardware configuration change to the computer system (e.g., addition of a hardware device to the computer system, removal of a hardware device from the computer system, a change in configuration of a hardware device of the computer system, etc.). In response, the hypervisor modifies a system table that is accessible by a guest operating system executing within a virtual machine.