A system includes a cache and a cache-management component. The cache includes a plurality of cache lines that correspond to a plurality of device endpoints. The cache-management component is configured to receive a transfer request block (TRB) for data transfer involving a device endpoint. In response to a determination that the cache both (i) does not include a cache line assigned to the device endpoint and (ii) does not include an empty cache line, the cache-management component assigns, to the device endpoint, a last cache line that includes a most recently received TRB in the cache, and stores the received TRB to the last cache line.